---
product_id: 717846466
title: "Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg"
brand: "vetoquinol"
price: "15418 kr"
currency: ISK
in_stock: true
reviews_count: 5
category: "Vetoquinol"
url: https://www.desertcart.is/products/717846466-vetoquinol-zylkene-calming-support-supplement-for-large-dogs-33-132lbs
store_origin: IS
region: Iceland
---

# Lactose-free & gentle on sensitive stomachs 450mg Alpha-Casozepine milk protein Supports large dogs 33-132 lbs Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg

**Brand:** vetoquinol
**Price:** 15418 kr
**Availability:** ✅ In Stock

## Summary

> 🐾 Unlock calm confidence for your big buddy—because stress-free dogs are the new cool.

## Quick Answers

- **What is this?** Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg by vetoquinol
- **How much does it cost?** 15418 kr with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.is](https://www.desertcart.is/products/717846466-vetoquinol-zylkene-calming-support-supplement-for-large-dogs-33-132lbs)

## Best For

- vetoquinol enthusiasts

## Why This Product

- Trusted vetoquinol brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Vet-Approved Calm:** Clinically backed Alpha-Casozepine promotes natural relaxation without drowsiness or side effects.
- • **Gut-Friendly Formula:** Lactose-free, natural ingredients ensure calm without upsetting sensitive stomachs.
- • **Stress-Proof Your Dog:** Eases anxiety from travel, vet visits, loud noises, and separation with daily behavioral support.
- • **Effortless Administration:** Simply open the capsule and mix with food—no fuss, just peace of mind.
- • **Trusted by Trainers & Rescues:** Proven success stories from professionals and rescue groups highlight real-world effectiveness.

## Overview

Vetoquinol Zylkene is a 450mg natural calming supplement designed for large dogs (33-132 lbs). Featuring Alpha-Casozepine, a milk-derived protein, it promotes relaxation and reduces anxiety caused by external stressors like travel, vet visits, and loud noises. Lactose-free and gentle on sensitive stomachs, it’s veterinarian recommended for daily behavioral support and easy to administer by mixing into food.

## Description

Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg

Review: I am a Dog Trainer...I have an 8 year old and a 2.5 year old border collies that get along very well with each other. And Yes.. even as a trainer.. My 2.5 year old is fear reactive towards other dogs, and I wasn't able to bring my foster's into the same room with my 2.5 year old or take her places on account of her reactions towards other dogs and sometimes people, this never stopped me from trying to socialize her more and help her cope. I recently adopted another puppy hoping to start out with a younger dog to work on training her to be less reactive. When I took my puppy to the vet for her shots, I discussed with my vet about putting my 2.5 year old on Prozac to help with coping and training. Which I was not to keen on a mind altering drug such a Prozac. My Vet told me about Zylkene and that it is non-prescription, non mind altering and is a natural supplement that contains the same ingredients as mother's milk. Which has a calming effect on dogs. She recommended it for dogs with separation anxiety, fear of thunderstorms and anxiety with car rides etc... So I purchased a bottle from my vet and gave 1 capsule to my 2.5 year old BC. By evening my husband is calling me to see the 2.5 year old and my 12 week old romping, jumping and playing with each other in the yard. I was ecstatic... and almost in tears... she has been on them for 2 weeks every morning with her meals along with training. Her and my puppy or the best of buddies, non-stop playing, sleeping together, and sharing toys. My recent foster was so nervous on car rides and I had to take her to 2 meet and greets. Getting her in and out of the car was a battle. So I decided to try one on her. She did amazing, jumping in and out of the car on her own, no shaking, panting or whining. Dogs that are scared in a car will not take treats and actually eat them. She was mooching as many treats from me as she could, and eating them. I told the Foster group that I work with about Zylkene, and several of them have purchased this product to use during transporting from rescue to foster homes or when we transport fosters to their new homes. I am recommending this to client's, rescues, and friends for their own dogs. This works really well and along with proper training, this does not have to be a life long supplement for your dog.
Review: I’ve use this product on my last 3 German Shepherds with great results. It really takes the edge off and my dogs have been so much happier on it. They listen better and mine was relaxed getting his nails trimmed at the vet yesterday. I was thrilled! Some days I also use calming treats in addition to the Zylkene if I need my almost 1 year old to settle down around company. It’s all about using layers of calming supplements. It all depends on your dog’s anxiety level. Worth the cost for peace of mind!

## Features

- Help Your Pet Cope With External Stress - Zylkene helps your pet cope with changes in their daily routine, such as travel, celebrations, vet visits, home alone, boarding, loud noises, and more
- Alpha-Casozephine - A naturally occurring milk protein found in cow's milk that helps promote calming effects in your pet without drowsiness or other side effects found in other calming chews for dogs
- Lactose-Free and Easy on Sensitive Stomachs - Zylkene's dog calming and cat calming supplements are lactose-free and made with natural ingredients that are easy on sensitive stomachs
- Veterinarian Recommended Daily Calming Support - Zylkene promotes calming in dogs and cats and can be given daily for behavior support and to help deal with unexpected external stresses
- Easy to Administer - Open the capsule of Zylkene and add it to your pet's food daily to help them cope with external stresses like separation and improve daily behavior

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B08T9ZN8BG |
| Batteries Included | No |
| Breed Recommendation | Large Breeds |
| Customer Reviews | 3.9 3.9 out of 5 stars (777) |
| Date First Available | 16 November 2016 |
| Flavor | Milk |
| Item Form | Capsule |
| Item Weight | 18 g |
| Item model number | 443962 |
| Number of Items | 1 |
| Package Dimensions | 11.51 x 7.49 x 2.31 cm; 18 g |
| Pet Life Stage | Adult |
| Quantity | 2 |
| Size | 14 Count (Pack of 1) |
| batteries required | No |

## Product Details

- **Brand:** Vetoquinol
- **Dog Breed Size:** Large
- **Flavour:** Milk
- **Item form:** Capsule

## Images

![Vetoquinol Zylkene Calming Support Supplement for Large Dogs 33-132lbs, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs, 450mg - Image 1](https://m.media-amazon.com/images/I/41SFudlFarL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: How long does it take for this to work to trim my dogs nails?**
A: My guess is that it depends on your dog and their level of anxiety.  This calming supplement did not work for our basset hounds.  Best of luck to you!

**Q: Will this help my dog to sleep all night?**
A: didnt help my dog

**Q: Description says 14 ct but picture shows 10 ct. Are there 14 capsules or 10?**
A: The package I purchased and received was 14 count.

**Q: How long before a vet visit?**
A: This is a supplement, so I don’t necessarily know that you need to visit with a vet before purchasing this item for pre authorization, assuming that’s what your question is in regards to, but it’s hard to tell bc you have given absolutely no context.

With regard to this item, it did not work for us, so we finally used Critter Ear (ear plugs for dogs) and we’ve been happy ever since! Dogs can’t fear what they don’t hear!

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by P***S on 20 December 2016*

I am a Dog Trainer...I have an 8 year old and a 2.5 year old border collies that get along very well with each other. And Yes.. even as a trainer.. My 2.5 year old is fear reactive towards other dogs, and I wasn't able to bring my foster's into the same room with my 2.5 year old or take her places on account of her reactions towards other dogs and sometimes people, this never stopped me from trying to socialize her more and help her cope. I recently adopted another puppy hoping to start out with a younger dog to work on training her to be less reactive. When I took my puppy to the vet for her shots, I discussed with my vet about putting my 2.5 year old on Prozac to help with coping and training. Which I was not to keen on a mind altering drug such a Prozac. My Vet told me about Zylkene and that it is non-prescription, non mind altering and is a natural supplement that contains the same ingredients as mother's milk. Which has a calming effect on dogs. She recommended it for dogs with separation anxiety, fear of thunderstorms and anxiety with car rides etc... So I purchased a bottle from my vet and gave 1 capsule to my 2.5 year old BC. By evening my husband is calling me to see the 2.5 year old and my 12 week old romping, jumping and playing with each other in the yard. I was ecstatic... and almost in tears... she has been on them for 2 weeks every morning with her meals along with training. Her and my puppy or the best of buddies, non-stop playing, sleeping together, and sharing toys. My recent foster was so nervous on car rides and I had to take her to 2 meet and greets. Getting her in and out of the car was a battle. So I decided to try one on her. She did amazing, jumping in and out of the car on her own, no shaking, panting or whining. Dogs that are scared in a car will not take treats and actually eat them. She was mooching as many treats from me as she could, and eating them. I told the Foster group that I work with about Zylkene, and several of them have purchased this product to use during transporting from rescue to foster homes or when we transport fosters to their new homes. I am recommending this to client's, rescues, and friends for their own dogs. This works really well and along with proper training, this does not have to be a life long supplement for your dog.

### ⭐⭐⭐⭐⭐ Review
*by A***. on 3 November 2025*

I’ve use this product on my last 3 German Shepherds with great results. It really takes the edge off and my dogs have been so much happier on it. They listen better and mine was relaxed getting his nails trimmed at the vet yesterday. I was thrilled! Some days I also use calming treats in addition to the Zylkene if I need my almost 1 year old to settle down around company. It’s all about using layers of calming supplements. It all depends on your dog’s anxiety level. Worth the cost for peace of mind!

### ⭐⭐⭐⭐ Review
*by R***T on 18 April 2019*

Zylkene capsules seem to be working really well, my dog is nervous anytime we go out of her comfort zone of our house or car. I give one of these capsules with her breakfast every morning, and it does seem to help all day. It is made to feed as a supplement, and there is no vet prescription needed. It is a little on the expensive side for a Calming aid for you pet, but if it helps, it is well worth every penny. My vet told me about it, so thought is was worth the try. It does seem to calm my dogs nerves!

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*Product available on Desertcart Iceland*
*Store origin: IS*
*Last updated: 2026-02-24*