Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

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Well it worked for me! I discovered Sam-e while doing some research on my own and decided to give it a try for my mild to moderate depression problems. It worked for me after about a week I started to notice a difference in my mood, I had more energy, and I was able to concentrate again. A few weeks after that i decided i didn't need it anymore and went off of it and a few days later I woke up feeling terrible with the same unpleasant feelings I had before I started taking it. Needless to say that night I went to the supermarket and bought some more. Now I just buy it from amazon because I know I need it and it offers the best value. I'll happily dish out forty bucks every two months if it helps me feel like this. I will note though that at first when I was switching brands I did have some gastrointestinal discomfort that was really unpleasant at first. It lasted off and on about three weeks, but then it stopped and I haven't had it since. I changed my diet to make sure I got about the same amount of fiber everyday to try and combat those problems and for me that seemed to work. I take one 400mg tablet every morning on an empty stomach and wait thirty minutes to an hour before eating anything. One time I ate something a few minutes after taking it and I did vomit so there's your warning, they actually do mean it when they say to wait to eat. Overall, I'm extremely happy with this product and if you don't believe these reviews look up some scholarly articles on it and the research speaks for itself, I believe they actually prescribe it for mild to moderate depression in countries like Germany. I've also read that st. john's wort works too for depression problems, but I've never tried it. A warning about st. john's though it can mess with the efficacy of birth control pills so I would be cautious about st. john's wort if you're taking birth control.

Sam-e is only thing I found that helps my depression.

this product is worth buying it helped my joint pain and added calmness as well

I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.