









🐾 Stay ahead of fleas with Advantage II—because your cat deserves the best defense!
Advantage II Large Cat is a vet-recommended, fragrance-free topical flea treatment designed for cats over 9 lbs and 8 weeks old. It kills adult fleas, larvae, and eggs within 12 hours and provides continuous protection for 30 days. Waterproof after 24 hours, this easy-to-apply treatment requires no prescription and effectively breaks the flea life cycle to keep your cat comfortable and flea-free.












| ASIN | B07N9LSPRY |
| Active Ingredients | Imidacloprid, Pyriproxyfen |
| Age Range Description | 8 weeks and older |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #67 in Pet Supplies ( See Top 100 in Pet Supplies ) #1 in Cat Flea Drops |
| Brand | Advantage |
| Brand Name | Advantage |
| Customer Reviews | 4.5 out of 5 stars 77,630 Reviews |
| Global Trade Identification Number | 00724089114969 |
| Item Form | Topical |
| Item Type Name | Topical |
| Item Volume | 0.8 Milliliters |
| Item Weight | 0.04 Pounds |
| Manufacturer | Elanco US Inc |
| Manufacturer Part Number | 90204382 |
| Model Number | 90204382 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Cat |
| UPC | 724089114969 |
| Unit Count | 1 Count |
| Volume | 0.8 Milliliters |
T**H
Fast relief for stressed out cats and tired owners.
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =)
V**R
IT WORKS! 24 hours after application and NO LIVE FLEAS.
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose.
T**Y
Very easy to Apply and it Works.
I went through hell for a year with fleas on my kitty girl ...I bug bombed my house twice and used several brands of flea shampoo twice a week. Nothing worked until I used this Advantage. So much easier and the fleas started dying the next day. In a week they were all dead and gone. I now use this every month and she sleeps well and is so much happier too. Yes it's expensive but it works fast and kills the eggs and larvae too.
S**L
No adverse reactions noted and effective.
Worked well for our cats. We have two three year old large maine coons and a four year old large rag doll. We used the Capstar pill first and then applied the Advantage topical 8 hours later. They had no reaction to the Advantage, aside from stopping itching. We travel with them and for the first time they picked up a few fleas during our recent September trip. So we wanted something pretty quickly to prevent the fleas from multiplying and causing ongoing issues. This combo worked well. We are noticing that they are scratching a bit now, but it is early for their second monthly treatment and we haven't found any live fleas. So I'm not quite sure what the occasional itching is about now. Overall, this flea method worked well though. The capstar does make cats run and get agitated for an hour or so since it kills the fleas on them and I guess they feel the fleas moving on them as they die. Aside from zoomys, and excessive self grooming the first few hours after ingesting the Capstar pill, no other issues though. And there was no observable reaction to the Advantage topical at all.
T**E
Reliable Flea Protection That Works Quickly
I’ve been using Advantage II for my large cat (over 12 lbs), and it’s the only flea treatment I fully trust. Within just a day of applying it, I noticed a big difference—scratching stopped, and I wasn’t finding fleas on her bedding anymore. By the second day, the fleas were completely gone. Application is simple: just part the fur at the base of the neck and apply directly to the skin. My cat tolerates it well, and the formula dries quickly without leaving a greasy mess. I also appreciate that it’s waterproof after 24 hours, so I don’t have to worry if she gets into a little rain or needs a bath. The 4-month supply is cost-effective compared to buying single doses, and I like knowing I can stay ahead of any infestations. This product really delivers on prevention as well—no fleas have come back in between monthly doses. If you have a bigger cat and need something safe, effective, and vet-recommended, this is an excellent choice. It gives peace of mind and keeps both your cat and your home flea-free. Highly recommend!
L**Y
Fleas are controlled
Great for flea prevention and treatment. Works better than other products I’ve tried.
D**A
Gone by the first dose!
I like the idea of putting it on the cats neck so they don’t lick it! My cat had a horrendous case of fleas and this solved it with the first dose! I added the second for precaution, but by the first it was completely gone. I recommended the dog version to my sister for her dog and same thing!!! It doesn’t have a bad smell but there’s definitely something there.
J**D
Doesn't kill fleas just immobilizes them for flea combing.
It works. Doesn't kill fleas more immobilizes them so you still have to flea comb them. Mostly angry that I could only buy a 4 pack because a 6 pack would take a month to get to me. So I paid more than I should have.
Trustpilot
2 weeks ago
5 days ago