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🛡️ Stay ahead of pests with the vet-trusted, month-long shield your dog deserves!
FRONTLINE Plus Flea & Tick Spot Treatment delivers fast, waterproof, and month-long protection for medium dogs (23-44 lbs). Featuring fipronil and (S)-methoprene, it kills fleas at all life stages, ticks, and chewing lice, breaking the infestation cycle. Trusted by pet owners for over 20 years, this easy-to-apply topical treatment continuously replenishes through sebaceous glands, ensuring reliable defense even after swimming or bathing.


















| ASIN | B07NGRSVLF |
| Active Ingredients | fipronil and (S)-methoprene |
| Age Range Description | All Life Stages |
| Allergen Information | Gluten Free |
| Best Sellers Rank | #1,045 in Pet Supplies ( See Top 100 in Pet Supplies ) #10 in Dog Flea Drops |
| Brand | Frontline |
| Brand Name | Frontline |
| Customer Reviews | 4.4 out of 5 stars 18,480 Reviews |
| Dog Breed Size | Medium |
| Included Components | Applicator |
| Item Form | Liquid |
| Item Type Name | Topical |
| Item Volume | 6 ml |
| Item Weight | 9.07 g |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer Part Number | 65331-5 |
| Model Number | 72218 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Medium Dog, 23-44 Pounds |
| UPC | 611030624557 350604062455 |
| Unit Count | 1 Count |
| Volume | 6 ml |
| Warranty Description | If you are not satisfied with Frontline Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842. |
S**L
Works for about 3 1/2 weeks.
Works well. Results take a few days to start and last just about one month before my dog scratches again. Slight oily change in his coat where applied to shoulders skin. Dries within a few hours. No noticeable odor.
W**S
Best you can get
Works as it should it’s great for fleas and ticks especially if you live in wooded or rural areas
J**A
Good product
Seems to be working. She has no fleas or ticks. I'm happy with the product
A**.
Trusted protection, but effectiveness can vary by region
This is a well-known and trusted flea & tick treatment that’s easy to use and works as part of a monthly routine. Each application provides about 30 days of protection, and the formula is designed to kill adult fleas, eggs, larvae, ticks, and even chewing lice. Application is simple—just apply it to the back of your dog’s neck, and it spreads through the oils in the skin for full-body protection. It’s also waterproof after drying, which is helpful for active dogs. In terms of performance, it works well for many dogs and can kill adult fleas within about 12 hours and ticks within 48 hours, helping break the flea life cycle. On the downside, effectiveness can vary depending on your area—some users report it’s not as strong as it used to be, especially in high-flea regions. It can also take a full day or so to start working, and you’ll need to stay consistent with monthly use.
K**R
Great stuff
Works as always
B**E
Don’t touch the treatment spot
No odor, but the area of use stays wet for a little while, so don’t pet it there. You don’t want to rub it in your eyes.
V**E
Bad batch
Didn't work. I have bought front line for years for my dogs and it's always done me good in the past. This batch didn't. This time when I applied it, it didnt do anything and i ended up with the worst fleas I've ever had. I decided to wait a few days, I know in some cases it takes time for the medication to work. After a few days I couldn't take it anymore, the fleas were out of control. Had to pull the combination of dawn dish soap and coconut oil out to get rid of them. Normally you would buy this stuff as a deterrent or treatment but I felt like it attracted them. Now I'm wondering if I should hope that I got a bad box or maybe it's time to switch to a different flea deterrent..
A**E
Works well
Does good job Use all summer
Trustpilot
1 month ago
1 week ago